Massively parallel DNA sequencing apparatus
AssigneeRoswell Biotechnologies, Inc.
InventorsChulmin Choi, Sungho Jin, Paul W. Mola, Barry L. Merriman
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Abstract
A DNA or genome sequencing structure is disclosed. The structure includes an electrode pair, each electrode having a tip-shaped end, the electrodes separated by a nanogap defined by facing tip-shaped ends; at least one conductive island deposited at or near each tip-shaped end; and a biomolecule having two ends, each end attached to the conductive islands in the electrode pair such that one biomolecule bridges over the nanogap in the electrode pair, wherein nucleotide interactions with the biomolecule provides electronic monitoring of DNA or genome sequencing without the use of a fluorescing element.
Claims20
A DNA or genome sequencing structure comprising:
- an electrode pair comprising a first metal, each electrode tapering to a tip-shaped end, with the electrodes separated by a nanogap configured to receive a biomolecule;
- and
- a conductive island of a second metal or metal alloy deposited at or near each tip-shaped end of each electrode wherein the first and second metals are different;
- wherein the biomolecule and the electrode pair form a stationary electronic circuit to detect composition of the biomolecule.
A DNA or genome sequencing system, comprising:
- an electrode pair of a first metal disposed on a substrate, each electrode tapering to a tip-shaped end, with the electrodes separated by a nanogap defined by the tip-shaped ends facing one another;
- at least one conductive island deposit of a second metal or metal alloy on each electrode at a location at or near each tip-shaped end of each electrode;
- a biomolecule having two ends, each end of the biomolecule attached to the at least one conductive island deposit on each electrode such that the biomolecule bridges the nanogap;
- and
- a chamber encasing the electrode pair and defining a microfluidic subsystem configured to supply a solution to the electrode pair;
- wherein the first and second metals are compositionally different.
Dependencies are inferred from the claim text.