Method of diagnosing a dysbiosis
AssigneesmartDNA Pty Ltd
InventorMargaret Smith
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to methods of diagnosing a dysbiosis in a subject, methods of determining a suitable treatment, and methods of treating a dysbiosis. In some aspects, the present disclosure relates to diagnosing or determining a subtype of irritable bowel syndrome (IBS).
Claims13
A method of diagnosing and treating a dysbiosis in a human subject, comprising measuring an abundance of at least 5 species of bacteria in a sample from the subject and at least 5 species of bacteria in a sample derived from a reference population, wherein the at least 5 species of bacteria include Corynebacterium minutissimum, Prevotella oulora, Fusobacterium naviforme, Prevotella ruminicola, and Bifidobacterium thermacidophilum, and wherein a diagnosis of is made when the abundance of one or more species of bacteria differs in abundance between the sample from the human subject and the sample derived from the reference population;
- and treating the subject for dysbiosis by administering to the subject a composition to the subject which increases and/or decreases the abundance of the one or more species of bacteria that differs in abundance between the sample from the human subject and the sample derived from the reference population.
A method of diagnosing and treating a dysbiosis in a human subject, comprising measuring an abundance of at least one species of each of 5 genera of bacteria in a sample from the subject and at least one species of each of 5 genera of bacteria in a sample derived from a reference population, wherein the at least 5 genera of bacteria include Corynebacterium, Lachnobacterium, Propionibacterium, Kytococcus, and Fusobacterium, and wherein a diagnosis of dysbiosis is made when the abundance of one or more genera of bacteria differs in abundance between the sample from the human subject and the sample derived from the reference population;
- and treating the subject for dysbiosis by administering to the subject a composition which increases and/or decreases the abundance of the at least one species of the one or more genera of bacteria in the subject, thereby treating the subject.
A method of determining a subtype of IBS in a human subject with IBS and treating the subject, comprising a) measuring an abundance of at least 5 species of bacteria in a sample from the subject, wherein the at least 5 species of bacteria include Christensenella minuta, Soleaferrea massiliensis, Papillibacter cinnamivorans, Oscillibacter valericigenes, and Ruminococcus bromii and comparing the abundance of the at least 5 species of bacteria in the sample from the human subject to the abundance of the at least 5 species of bacteria in a sample derived from a reference population thereby determining a subtype of IBS;
- and b) administering a composition to the subject which increases and/or decreases the abundance of one or more species of bacteria in the subject, thereby treating the subject.
Dependencies are inferred from the claim text.