Producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam in the presence of methanol using a microorganism having increased availability of reducing equivalents

A method for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam, comprising culturing a non-naturally occurring microbial organism comprising:

• (A) a methanol metabolic pathway, wherein said organism comprises at least one exogenous nucleic acid encoding a methanol metabolic pathway enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of methanol compared to said organism not comprising said at least one exogenous nucleic acid encoding a methanol metabolic pathway enzyme, wherein said methanol metabolic pathway comprises:
• (i) a methanol methyltransferase and a methylenetetrahydrofolate reductase;
• (ii) a methanol dehydrogenase;
• or
• (iii) a methanol dehydrogenase and a formaldehyde activating enzyme;
• and
• (B) (i) an adipate pathway, (ii) a 6-aminocaproate pathway, (iii) a hexamethylenediamine pathway, or (iv) a caprolactam pathway,
• under suitable conditions and for a sufficient period of time to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.