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US 11,447,779 B2Granted
Immunostimulatory compositions
AssigneeBayer Animal Health GmbH
InventorThomas Ilg
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to immunostimulatory compositions that are effective in eliciting immune responses in avian species. More specifically, these immunostimulatory compositions comprise an immunomodulator composition and an immunostimulatory oligonucleotide that when administered stimulate toll-like receptor 21.
Claims47
An immunostimulatory composition comprising:
- a) an immunomodulator composition comprising a nucleic acid plasmid and a liposomal delivery vehicle;
- and
- b) an immunostimulatory oligonucleotide having at least one CpG motif and a guanine nucleotide enriched sequence at or near the 5′ terminus of the immunostimulatory oligonucleotide.
A method for stimulating toll-like receptor 21 (TLR21) comprising:
- administering an immunostimulatory oligonucleotide and an immunomodulator composition, wherein the immunostimulatory oligonucleotide has at least one CpG motif and a guanine nucleotide enriched sequence at or near the 5′ terminus of the immunostimulatory oligonucleotide, and wherein the immunomodulator composition comprises a noncoding nucleic acid plasmid and a lipid delivery vehicle.
An immunostimulatory composition comprising:
- a. a nucleic acid plasmid and a liposomal delivery vehicle;
- and
- b. an immunostimulatory oligonucleotide comprising SEQ ID NO:1.
Dependencies are inferred from the claim text.