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US 11,447,778 B2Granted
TNF-targeting aptamers and uses thereof for treatment or diagnosing TNF-related inflammatory diseases
AssigneesAcademia Sinica, National Taiwan University
InventorsPan-Chyr Yang, Wei-Yun Lai, Jen-Wei Wang
Life of this patent
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Abstract
Nucleic acid aptamers that bind to tumor necrosis factor alpha (TNF). Also provided herein are pharmaceutical compositions comprising such anti-TNF aptamers and methods for the using the same for therapeutic and diagnostic applications, for example, alleviating liver injury and monitoring presence of TNF in vivo or in vitro.
Claims28
A nucleic acid aptamer capable of binding human tumor necrosis factor alpha (TNFα), wherein the aptamer comprises a nucleic acid sequence that is at least 85% identical to
- (SEQ ID NO:
- 1)
- GCGCCACTACAGGGGAGCTGCCATTCGAATAGGTGGGCCGC.
Dependencies are inferred from the claim text.