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US 11,447,774 B2Granted
Nuclease systems for genetic engineering
AssigneesThe Board of Trustees of the Leland Stanford Junior University, Intima Bioscience, Inc.
InventorsLei S. Qi, Modassir S. Choudhry, Xueqiu Lin, Xiaoshu Xu
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Abstract
Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.
Claims17
A nucleic acid editing system comprising:
- (i) an Argonaute polypeptide from a mesophilic organism;
- (ii) a guide nucleic acid;
- and
- (iii) a nucleic acid unwinding agent,
- wherein upon contacting a target nucleic acid with said nucleic acid editing system at a mesophilic temperature, said system cleaves the target nucleic acid.
2 more elements
Dependencies are inferred from the claim text.