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US 11,447,771 B1Granted
CRISPR DNA targeting enzymes and systems
AssigneeArbor Biotechnologies, Inc.
InventorsDavid R. Cheng, David A. Scott, Winston X. Yan
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Abstract
The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR-Cas systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.
Claims22
An engineered, non-naturally occurring Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)—associated (Cas) system comprising:
- (a) an RNA guide or a nucleic acid encoding the RNA guide, wherein the RNA guide comprises a direct repeat sequence and a spacer sequence;
- and
- (b) a CRISPR-Cas effector protein or a nucleic acid encoding the CRISPR-Cas effector protein, wherein the CRISPR-Cas effector protein comprises the amino acid sequence set forth in SEQ ID NO:
- 127,
- wherein the CRISPR-Cas effector protein binds to the RNA guide, wherein the spacer sequence comprises a sequence complementary to a target nucleic acid, and wherein the spacer sequence binds to the target nucleic acid.
2 more elements
Dependencies are inferred from the claim text.