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US 11,447,753 B2Granted
Non-neuroinvasive viruses and uses thereof
AssigneesNorthwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College (AKA Tufts University)
InventorsGregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
Life of this patent
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Abstract
Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
Claims19
A variant herpesvirus virus particle comprising at least two mutations in a UL37 protein comprising a polypeptide, having at least 90% identity to SEQ ID NO:
- 28, wherein the mutations are at positions selected from the group consisting of Q376, D424, Q427, and R486 in SEQ ID NO:
- 28, wherein said virus particle exhibits reduced neuro-invasiveness relative to a virus particle lacking said mutation, wherein the ability of the virus to replicate in peripheral tissues is retained.
Dependencies are inferred from the claim text.