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US 11,447,748 B2Granted
Encapsulated adipose-derived stem cells, methods for preparation and theraputic use
AssigneeJointTechLabs, Inc.
InventorsNathan Katz, Felix Pustilnik
Life of this patent
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Abstract
A therapeutic composition comprising a purified fraction of adipose-derived mesenchymal stem cells encapsulated in a three-dimensional biocompatible gel matrix, and methods, and systems for preparing and using encapsulated adipose-derived mesenchymal stem cells. Hydrogel microbeads encapsulating stem cells maintain the viability and location of the stem cells for an extended period as compared to stem cells in suspension. The gel matrix allows the release of cellular factors from the encapsulated stem cells to surrounding tissues to achieve desired therapeutic results.
Claims15
A method for treating a patient comprising:
- (a) receiving a therapeutic composition comprising an injectable suspension of a plurality of microbeads of a biocompatible hydrogel,
- wherein each microbead comprises from about 2,000 to about 10,000 adipose-derived stem cells encapsulated within the hydrogel;
- and
- wherein the microbeads are adapted to release cellular factors from the stem cells to a target tissue of the patient into which the microbeads are introduced;
- (b) introducing said therapeutic composition adjacent a diseased or injured tissue in the patient;
- and
- (c) causing the release of therapeutic cellular factors from said stem cells encapsulated within the hydrogel to said diseased or injured tissue.
4 more elements
Dependencies are inferred from the claim text.