Cell culture substrate comprising fluorine-containing polymer on its surface

A cell culture substrate having a smooth surface at least a part of which is composed of a resin composition comprising a fluorine-containing polymer having one or more fluorine atoms in a repeating unit, wherein the oxygen gas permeability of the cell culture substrate is 219 cm3 (STP)/(m2·24 h·atm) or higher, and wherein the smooth surface has a center line average roughness of 0.5 μm or less,

• wherein the fluorine-containing polymer comprises:
• (I) at least one type of fluorine-containing polyimide selected from the group consisting of:
• (a) an aromatic polyimide comprising a repeating unit represented by formula (V):
• wherein
• p is 0 or 1;
• X1 is —C(CF3)2—,
• all of Z1, Z2, Z3, Z4, Z5, and Z6 are hydrogen atoms or fluorine atoms;
• Y1 comprises at least one of:
• and
• at least one of X1, Y1, Z1, Z2, Z3, Z4, Z5, and Z6 comprises a fluorine atom;
• provided
• if X1 is —C(CF3)2—, then Y1 is
• if p is 0, then Y1 is
• (b) an aromatic polyimide comprising a repeating unit represented by formula (V):
• wherein
• p is 0 or 1;
• X1 is —S—,
• all of Z1, Z2, Z3, Z4, Z5, and Z6 are hydrogen atoms or fluorine atoms;
• Y1 comprises at least one of:
• and
• at least one of X1, Y1, Z1, Z2, Z3, Z4, Z5, and Z6 comprises a fluorine atom;
• and
• (c) a fluorine-containing polyimide comprising in its main chain a repeating unit represented by Formula (3):
• wherein
• X0 represents a tetravalent organic group;
• Y0 represents a divalent organic group;
• X0 and Y0 contain one or more fluorine atoms in total;
• and
• Y0 is a group represented by Formula (D):
• wherein one of R11, R12, R13, R14, and R15 represents a single bond to a nitrogen atom, and 4 other members each independently represent a group selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, —SO3H, and —OH;
• and
• wherein one of R21, R22, R23, R24, and R25 represents a single bond to a nitrogen atom, and 4 other members each independently represent a group selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, —SO3H, and —OH;
• or R11 and R21 and/or R15 and R25 may together form —S(═O)2—;
• or
• (II) a polymer having a fluorine-containing aromatic ring and having an ether bond in its main chain represented by Formula (II-2):
• wherein n represents the degree of polymerization, m is 0 or 1, and R41 is a group represented by Formula (II-3):
• wherein p is the integer 0 or 1, and R42 represents a structure represented by any of the formulae shown below: