Cyclodextrin based polymers, methods, compositions and applications thereof
AssigneeAten Porus Lifesciences
InventorsAditya Kulkarni, Atul Dolas, Princy Khurana, Soniya Johny, Manu Manjunath
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Abstract
The present disclosure relates to polymers comprising conjugates of cyclodextrin or derivatives thereof and a linker moiety, methods of preparing the same and their application in the removal of lipids such as cholesterol from cells in treating lipid storage disorders. The present polymers exhibit improved properties including but not limiting to improved biocompatibility, improved retention time, prolonged duration of action in cells, and increased efficacy in removal of cholesterol from cells in treating lipid storage disorders.
Claims20
A polymer comprising the following structure:
- wherein:
- CD is a cyclodextrin moiety;
- L is a linker moiety having the structure:
- wherein:
- Ar1 and Ar2 are each independently a 5- or 6-membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms individually selected from N, O, and S, wherein Ar1 and Ar2 are optionally substituted with R3;
- each Y is independently O, S, or NR4;
- m and p are each independently an integer from 1 to 10;
- R1 and R2 are each independently R4, OR4, S, or R1 and R2 together form a double bonded O, S, or NR4;
- R3 is selected from C1-C3 alkyl, C1-C3 alkyl sulphide, hydrazine, amine and halogen;
- R4 is H or a saturated or unsaturated C1-C10 linear alkyl, saturated or unsaturated C1-C10 branched alkyl, or saturated or unsaturated C1-C10 cycloalkyl, each of which is optionally substituted;
- and
- n is from 4 to 1000.
Dependencies are inferred from the claim text.