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US 11,447,573 B2Granted
Multispecific antigen binding proteins and methods of use thereof
AssigneeNanjing Legend Biotech Co., Ltd.
InventorsChuan-Chu Chou, Yafeng Zhang, Shu Wu, Zhenyu Liu, Zhongdao Li, Fangliang Zhang
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Abstract
Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
Claims19
A multispecific antigen binding protein comprising:
- (a) a first antigen binding portion comprising a single-chain variable fragment (scFv) comprising a heavy chain variable domain (VH) and a light chain variable domain (VL), wherein the scFv specifically binds a first epitope,
- (b) a second antigen binding portion comprising a single-domain antibody (sdAb) that specifically binds a second epitope, and
- (c) Fc region,
- wherein the first antigen binding portion and the second antigen binding portion are fused to each other, and wherein the N-terminus of the sdAb is fused to the C-terminus of the scFv and the C-terminus of the sdAb is fused to the N-terminus of the Fc region.
1 more element
Dependencies are inferred from the claim text.