Binding unit targeting fibroblast activation protein α and application thereof
AssigneeCrage Medical Co., Limited
InventorsZonghai Li, Peng Wang
Life of this patent
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Abstract
A binding unit that specifically binds to fibroblast activation protein α (FAPα), a polynucleotide that encodes the binding unit, a vector that comprises the polynucleotide and a host cell, a method for use in producing the antigen-binding unit and a method for treating a disease by using the FAPα-specific binding unit; the binding unit that specifically binds to FAPα may efficiently bind to tumor cells that express FAPα, and immune effector cells comprising the binding unit exhibit significant killing capabilities against tumor cells that express FAP.
Claims12
An antigen binding unit for targeting fibroblast activation protein alpha (FAPα), comprising:
- a light chain variable region and a heavy chain variable region,
- wherein the heavy chain variable region comprises HCDR1, HCDR2, and HCDR3, and the light chain variable region comprises LCDR1, LCDR2, and LCDR3;
- the HCDR1 has the sequence as shown in SEQ ID NO:
- 1 or 7,
- the HCDR2 has the sequence as shown in SEQ ID NO:
- 2 or 8,
- the HCDR3 has the sequence as shown in SEQ ID NO:
- 3,
- the LCDR1 has the sequence as shown in SEQ ID NO:
- 4 or 9,
- the LCDR2 has the sequence as shown in SEQ ID NO:
- 5 or 10, and
- the LCDR3 has the sequence as shown in SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.