Methods and compositions for the treatment of ocular diseases and disorders

A method for treating or inhibiting an ocular disease in a subject in need thereof, said method comprising administering a therapeutically effective amount of at least one anti-ras homolog family member B (RhoB) antibody or antigen-binding fragment thereof to said subject,

• wherein said ocular disease is macular degeneration characterized by abnormal vascularization, and
• wherein said anti-RhoB antibody or antigen-binding fragment thereof comprises all six complementarity-determining regions (CDRs) of an antibody comprising SEQ ID NOs:
• 2 and 3 or an antibody comprising SEQ ID NOs:
• 4 and 5, and
• wherein the administration of the antibody or antigen-binding fragment thereof reduces abnormal neovascularization in the retina and reduces avascularization around the optic nerve.