Antibody constructs for FLT3 and CD3
AssigneeAmgen Research (Munich) GmbH
InventorsTobias Raum, Claudia Blümel, Franziska Bott, Christoph Dahlhoff, Patrick Hoffmann, Elisabeth Nahrwold, Jochen Pendzialek
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AssigneeAmgen Research (Munich) GmbH
InventorsTobias Raum, Claudia Blümel, Franziska Bott, Christoph Dahlhoff, Patrick Hoffmann, Elisabeth Nahrwold, Jochen Pendzialek
Estimating the term…
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
A bispecific antibody construct comprising a first binding domain which binds to human and macaque Fms-like tyrosine kinase 3 (FLT3) on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell, wherein the first binding domain comprises a VH region comprising CDR-H1, CDR-H2 and CDR-H3 and a VL region comprising CDR-L1, CDR-L2 and CDR-L3, wherein said CDR-HI, CDR-H2, CDR-H3, CDR-LI, CDR-L2, and CDR-L3 comprise the amino acid sequences selected from the group consisting of:
Dependencies are inferred from the claim text.