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US 11,447,563 B2Granted
Tumor selective macropinocytosis-dependent rapidly internalizing antibodies
AssigneeThe Regents of the University of California
InventorBin Liu
Life of this patent
Estimating the term…
Abstract
Methods are provided for identifying and selecting antibodies that are internalized into cells via the macropinocytosis pathway. Additionally antibodies that are internalized via this pathway are provided as well as immunoconjugates comprising such antibodies.
Claims19
An isolated antibody that is internalized into a cell via a macropinocytosis pathway, wherein said antibody comprises:
- a variable heavy (VH) domain comprising VH CDR1 consisting of the amino acid sequence SYAMH (SEQ ID NO:44) VH CDR2 consisting of the amino acid sequence VISYDGSNKYYADSVKG (SEQ ID NO:45), and VH CDR3 consisting of the amino acid sequence APAYSYGPFDY (SEQ ID NO:46) of antibody HCA-M1;
- and
- a variable light (VL) domain comprising VL CDR1 consisting of the amino acid sequence QGDSLRSYYAS (SEQ ID NO:51), VL CDR2 consisting of the amino acid sequence YGKNNRPS (SEQ ID NO:52), and VL CDR3 consisting of the amino acid sequence HSRDSSGTHLRV (SEQ ID NO:54) of antibody HCA-M1.
Dependencies are inferred from the claim text.