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US 11,447,556 B2Granted
OX40-binding polypeptides and uses thereof
AssigneeInhibex, Inc.
InventorsJohn C. Timmer, William Crago, Kyle Jones, Katelyn Willis, Florian Sulzmaier, Bryan Becklund, Brendan P. Eckelman
Life of this patent
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Abstract
Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.
Claims60
A polypeptide comprising at least one VHH domain that binds OX40, wherein the VHH domain comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 10, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 11, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 12, and wherein the VHH domain comprises a FR2 comprising the amino acid sequence of SEQ ID NO:
- 22.
1 more element
A polypeptide that binds OX40 consisting of the amino acid sequence of SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.