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US 11,447,552 B2Granted
Methods and compositions for inhibiting CD32B expressing cells
AssigneeXencor, Inc.
InventorsSeung Yup Chu, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Gregory L. Moore, Igor Vostiar
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Abstract
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
Claims6
An antibody comprising:
- at least one amino acid substitution in the Fc region comprising S267E, wherein the numbering is according to the EU index, as in Kabat;
- and
- a light chain variable region comprising SEQ ID NO:
- 1;
- and a heavy chain variable region comprising SEQ ID NO:
- 2.
3 more elements
An anti-CD19 antibody comprising:
- a) a light chain variable region comprising SEQ ID NO:1;
- b) a heavy chain variable region comprising SEQ ID NO:2;
- and
- c) a variant Fc human IgG domain comprising the amino acid substitution S267E, wherein the numbering is according to the EU index as in Kabat.
1 more element
Dependencies are inferred from the claim text.