Peptides for molecular detection of PD-L1
AssigneeThe Curators of the University of Missouri
InventorsRaghuraman Kannan, Charles Caldwell, Jr., Vitukudi Narayanaiyengar Balaji, Govardhan Aadharsh Balaji
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Abstract
This disclosure relates to synthetic ligands for detecting PD-L1 in a sample or subject. The ligand can be labeled with a variety of detectable labels allowing of visualization and quantification. The ligand provides an alternative PD-L1 binding molecule with advantages over current antibody technologies for detecting PD-L1.
Claims20
A detectably labeled synthetic ligand comprising a peptide or peptidomimetic compound, wherein the peptide or peptidomimetic compound comprises amino acid sidechains following the entire sequential order of the amino acid sequence SEQ ID NO:
- 1 and wherein the peptide or peptidomimetic compound has a length equal or equivalent to 19 to 39 amino acid residues.
A method of making a detectably labeled synthetic ligand for detecting PD-L1, the method comprising incorporating a detectable label into, or attaching either directly or via a spacer a detectable label to, a peptide or peptidomimetic compound that comprises amino acid sidechains following the entire sequential order of the amino acid sequence SEQ ID NO:
- 1, wherein the peptide or peptidomimetic compound has a length equal or equivalent to 19 to 39 amino acid residues.
Dependencies are inferred from the claim text.