Human antibodies binding to ROR2

A fully human antibody, or antigen-binding fragment thereof, which specifically binds to the extracellular domain of receptor tyrosine kinase-like orphan receptor 2 (ROR2)

• which comprises one of the following CDR sets:
• a) heavy chain CDRs 1-3 as set forth in SEQ ID NOs 38, 39 and 40, respectively, and light chain CDRs 1 and 3 as set forth in SEQ ID NOs 29 and 41, respectively, with light chain CDR 2 having the sequence KAS;
• b) heavy chain CDRs 1-3 as set forth in SEQ ID NOs 26-28, respectively, and light chain CDRs 1-3 as set forth in SEQ ID NOs 29, 73 and 30, respectively;
• c) heavy chain CDRs 1-3 as set forth in SEQ ID NOs 94, 32 and 44, respectively, and light chain CDRs 1 and 3 as set forth in SEQ ID NOs 29 and 42, respectively, with light chain CDR 2 having the sequence KAS;
• d) heavy chain CDRs 1-3 as set forth in SEQ ID NOs 38, 46 and 52, respectively, and light chain CDRs 1 and 3 as set forth in SEQ ID NOs 50 and 53, respectively, with light chain CDR 2 having the sequence AAS;
• e) heavy chain CDRs 1-3 as set forth in SEQ ID NOs 38, 54 and 55, respectively, and light chain CDRs 1 and 3 as set forth in SEQ ID NOs 56 and 57, respectively, with light chain CDR 2 having the sequence LGS;
• f) heavy chain CDRs 1-3 as set forth in SEQ ID NOs 58-60, respectively, and light chain CDRs 1 and 3 as set forth in SEQ ID NOs 61, and 62, respectively, with light chain CDR 2 having the sequence KAS,
• g) heavy chain CDRs 1-3 as set forth in SEQ ID NOs 63-65, respectively, with light chain CDRs 1 and 3 as set forth in SEQ ID NOs 50 and 66, respectively, with light chain CDR 2 having the sequence AAS.