High avidity antigen recognizing constructs
AssigneeMax-DelbrüCk-Centrum FüR Molekulare Medizin (Mdc) Berlin-Buch
InventorsThomas Blankenstein, Matthias Obenaus, Catarina Leitâo
Life of this patent
Estimating the term…
Abstract
The present invention pertains to novel high avidity antigen recognizing constructs, such as antibodies or T cell receptors, which specifically bind to the melanoma associated antigen (MAGE) A1. The constructs of the invention are particularly useful for the diagnosis, prevention or therapy of tumorous diseases which are characterized by the specific expression of the MAGE-A1 antigen. Furthermore provided are nucleic acids, vectors and host cells—such as CD4 or CD8 positive T cells—which encode, comprise or present the antigen recognizing constructs of the invention. The invention thus provides new approaches for immune therapy, specifically adoptive T cell therapy, for treating cancer.
Claims21
A nucleic acid encoding a T cell receptor (TCR), or a derivative or a fragment thereof that binds to MAGE-A1 antigen, wherein the TCR or derivative or fragment thereof comprises (i) an alpha chain comprising complementarity-determining regions (CDRs) having the amino acid sequences of SEQ ID NO:
- 40, 41, and 1;
- and (ii) a beta chain comprising CDRs having the amino acid sequences of SEQ ID NO:
- 46, 47, and 4.
A nucleic acid encoding a TCR, or a derivative or a fragment thereof that binds to MAGE-A1 antigen, wherein the TCR or derivative or a fragment thereof comprises (i) an alpha chain comprising CDRs having the amino acid sequences of SEQ ID NO:
- 42, 43, and 2;
- and (ii) a beta chain comprising CDRs having the amino acid sequences of SEQ ID NO:
- 48, 49, and 5.
A nucleic acid encoding a TCR, or a derivative or a fragment thereof that binds to MAGE-A1 antigen, wherein the TCR or derivative or fragment thereof comprises (i) an alpha chain comprising CDRs having the amino acid sequences of SEQ ID NO:
- 44, 45, and 3;
- and (ii) a beta chain comprising CDRs having the amino acid sequences of SEQ ID NO:
- 50, 51, and 6.
Dependencies are inferred from the claim text.