GLP-1 analogues

A polypeptide having the amino acid sequence:

• (SEQ ID NO:
• 4)
• H-X2-X3-X4-G-T-F-T-S-D-V-S-S-Y-L-X16-G-Q-A-A-X21-
• E-F-X24-A-W-L-V-R-G-R-G-X33-X34
• wherein X2 is Ser, Ser(OMe), D-Ser, D-Ser(OMe), Ala or Aib;
• X3 is absent or Gln;
• X4 is Glu;
• X16 is Glu;
• X24 is Ile;
• X33 is Leu, -D-Leu, D-Ile or Ile;
• X34 is absent;
• and
• X21 is Lys wherein the side chain amino group of Lys is acylated with a moiety:
• {-Q-T-U-W-Y-Z
• wherein Q and T are absent,
• U is absent or —C(O)—CH2—O—(CH2)2—O—(CH2)2—NH—} wherein} is point of attachment with group W;
• W is absent or selected from a group consisting of —C(O)—CH2—O—(CH2)2—O—(CH2)2—NH—], —C(O)—NH—(CH2)3-4—NH—], —C(O)—C(CH3)2—NH—];
• and
• wherein] is point of attachment with group Y;
• Y is —C(O)—(CH2)2—CH(COOH)NH— and — is point of attachment with the group Z;
• Z is —C(O)—(CH2)n—COOH or —C(O)—(CH2)n—CH3 wherein n is an integer from 14 to 20.