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US 11,447,532 B2Granted
Long uniform recombinant protein fibers
AssigneeBolt Threads, Inc.
InventorsDavid Breslauer, Joshua Kittleson, Loren Perelman, Lindsay Wray
Life of this patent
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Abstract
The present disclosure provides improved long uniform recombinant protein fibers with desirable physical traits. The present disclosure also provides compositions derived from the long uniform recombinant protein fibers.
Claims25
A long uniform recombinant protein fiber, comprising:
- a continuous fiber length of at least 600 m, wherein the mean properties along the length of the fiber comprise:
- a tenacity greater than or equal to 12 cN/tex;
- a linear density less than or equal to 6 dtex;
- a coefficient of variation of tenacity less than 15%;
- and
- a coefficient of variation of linear density less than 20%,
- wherein the tenacity is measured using ASTM D3822-14, and the linear density is measured using ASTM D1577;
- wherein the recombinant protein fiber comprises a protein sequence comprising repeat units, wherein
- each repeat unit has at least 95% sequence identity to a sequence that comprises from 2 to 20 quasi-repeat units,
- each quasi-repeat unit comprising a polypeptide of {GGY-[GPG-X1]n1-GPS-(A)n2} (SEQ ID NO:
- 111), wherein for each quasi-repeat unit:
- X1 is independently selected from the group consisting of SGGQQ (SEQ ID NO:
- 100), GAGQQ (SEQ ID NO:
- 101), GQGPY (SEQ ID NO:
- 102), AGQQ (SEQ ID NO:
- 103), and SQ;
- n1 is from 4 to 8;
- and n2 is from 6 to 10.
15 more elements
Dependencies are inferred from the claim text.