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US 11,447,526 B2Granted
Influenza virus vaccines and uses thereof
AssigneeJanssen Vaccines & Prevention B.V.
InventorsFerdinand Jacobus Milder, Tina Ritschel, Boerries Brandenburg, Mandy Antonia Catharina Jongeneelen, Daphné Truan, Johannes Petrus Maria Langedijk
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Abstract
Provided herein are influenza hemagglutinin stem polypeptides, nucleic acids encoding said polypeptides, vectors comprising said nucleic acid and pharmaceutical compositions comprising the same, as well as methods of their use, in particular in the prevention and/or treatment of influenza virus infections.
Claims34
A group 1 influenza A hemagglutinin (HA) stem polypeptide, comprising an HA1 and a HA2 domain, said HA stem polypeptide comprising an amino acid sequence which comprises:
- a deletion of the head region in the HA1 domain;
- (ii) a modification of the trimerization region in the HA2 domain;
- (iii) at least 2 cysteine residues forming an intramonomeric disulphide bridge;
- (iv) at least 2 cysteine residues forming an intermonomeric disulphide bridge;
- wherein the amino acid corresponding to the amino acid at position 392 is P, R or Y, and the amino acid corresponding to the amino acid at position 434 is Q, and wherein the numbering of the amino acid positions is based on H3 numbering as used in SEQ ID NO:
- 15.
3 more elements
Dependencies are inferred from the claim text.