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US 11,447,518 B2Granted
Phosphoramidates for the treatment of hepatitis B virus
AssigneeEmory University
InventorsAbel de la Rosa, Gregory R. Bluemling
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Abstract
Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
Claims14
A method of preparing a nucleoside phosphoramidate, comprising:
- contacting
- with a phosphoramidate in the presence of a base.
A method of synthesizing a pentafluorophenoxy-phenoxy-phosphorylamino ester, comprising:
- contacting a mixture comprising
- or a salt thereof and phenyl phosphorodichloride with a base to form a reaction mixture;
- contacting the reaction mixture with pentafluorophenol and additional base to form a product mixture;
- isolating a mixture of diastereomers from the product mixture;
- and
- isolating
- from the mixture of diastereomers, wherein
- the isolating
- from the mixture of diastereomers comprises combining the mixture of diastereomers with pentafluorophenol, base, and dimethylaminopyridine in ethyl acetate and hexanes;
- and isolating solid
- by filtration.
8 more elements
Dependencies are inferred from the claim text.