Crystal forms of crisaborole in free form and preparation method and use thereof
AssigneeAnacor Pharmaceuticals, Inc.
InventorsMinhua Chen, Yanfeng Zhang, Fei Lu, Nan Xia, Xiaoyu Zhang
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Abstract
The present invention relates to four crystal forms of crisaborole in free form and the preparation method thereof. The present invention also relates to the pharmaceutical composition containing the crystal forms and the use thereof.
Claims18
A crystalline Form I of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 14.1°±0.2°, 15.3°±0.2°, and 26.1°±0.2°, degrees two theta.
A crystalline Form I of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 16.0°±0.2°, 18.1°±0.2° and 24.8°±0.2°, degrees two theta.
A crystalline Form I of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 6.0°±0.2°, 21.4°±0.2° and 28.4°±0.2°, degrees two theta.
A crystalline Form II of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 16.6°±0.2°, 20.8°±0.2°, and 22.6°±0.2°, degrees two theta.
A crystalline Form II of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 17.6°±0.2°, 21.8°±0.2° and 27.9°±0.2°, degrees two theta.
A crystalline Form II of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 18.4°±0.2°, 21.4°±0.2°, and 23.1°±0.2°, degrees two theta.
A crystalline Form III of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 18.6°±0.2°, 20.6°±0.2° and 27.8°±0.2°, degrees two theta.
A crystalline Form III of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 13.6±0.2°, 19.5°±0.2° and 21.7°±0.2°, degrees two theta.
A crystalline Form III of 4-[(1,3-dihydro-1-hydroxyl-2,1-benzoxaborolane-5-yl)oxy]benzonitrile having an X-ray powder diffraction pattern comprising diffraction peaks at 16.3°±0.2°, 21.3°±0.2°, and 22.5°±0.2°, degrees two theta.
Dependencies are inferred from the claim text.