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US 11,447,501 B2Granted
Biphenyl-containing diarylpyrimido compounds, pharmaceutically-acceptable salts thereof, composition and preparation thereof
AssigneeFudan Univeristy
InventorsFener Chen, Yali Sang, Chunlin Zhuang
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Abstract
A biphenyl-containing diarylpyrimido compound of formula (I), which is prepared by reacting a 4-chloropyrimidine derivative with a biphenyl derivative in a solvent in the presence of a base. A pharmaceutically-acceptable salt of the compound (I) and a pharmaceutical composition containing the compound (I) or a pharmaceutically-acceptable salt thereof are also provided.
Claims10
A biphenyl-containing diarylpyrimido compound of formula (I):
- wherein:
- R1 is selected from the group consisting of hydrogen, cyano, nitro, hydroxyl, halogen, amino, C3-C6 cycloalkoxy, C3-C6 cycloalkylamino, substituted C1-C6 alkyl, substituted C2-C6 alkenyl, substituted C2-C6 alkynyl, C1-C6 alkoxy, carboxyl, ester group, amido and sulfonamido;
- R2 is selected from the group consisting of cyano, nitro, hydroxyl, halogen, amino, C3-C6 cycloalkoxy, C3-C6 cycloalkylamino, substituted C1-C6 alkyl, substituted C2-C6 alkenyl, substituted C2-C6 alkynyl, C1-C6 alkoxy, carboxyl, ester group, amido and sulfonamido;
- X is selected from the group consisting of —CH2—, —NH—, —O—, —S—, —S(O)— and —S(O)2—;
- and
- is selected from the group consisting of unsubstituted and substituted benzene ring;
- thiophene, thiazole, oxazole, isoxazole, pyrazolone, furan, pyridine, azine and an oxide thereof;
- cyclopentadiene;
- tetrahydrothiophene;
- sulphoxide;
- sulfone;
- tetrahydrofuran;
- and substituted cycloalkane.
10 more elements
Dependencies are inferred from the claim text.