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US 11,447,500 B2Granted
Thienopyridine derivatives and pharmaceutical composition comprising same
AssigneeWellmarker Bio Co., Ltd.
InventorsHyunho Lee, Chun-Ho Park, Sun Chul Hur, Jai-Hee Moon, Jae-Sik Shin, Seung-Woo Hong, Yoon-Sun Park, Joseph Kim, Sohee Lee, Hyojin Kim, Hyebin Park
Life of this patent
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Abstract
A thienopyridine derivative compound represented by Formula 1 or pharmaceutically acceptable salts thereof have an excellent inhibitory effect on protein kinase activity, and accordingly, pharmaceutical compositions containing the thienopyridine compound can be usefully used for the prevention or treatment of a disease associated with the activity of a protein kinase.
Claims15
A compound represented by the following Formula 1, or a pharmaceutically acceptable salt thereof:
- wherein
- R1 and R2 are each independently H, halogen, C1-10 alkoxy, or halo C1-10 alkyl;
- X is —C(—R3)═ or —N═;
- R3 and R4 are each independently H, halogen, C1-10 alkyl, or C1-10 alkoxy;
- R5 is H, halogen, or C1-10 alkyl;
- and
- R6 and R7 are each independently H, C1-10 alkyl, or —(CH2)n—Y—R8, or R6 and R7, taken together with the N atom to which they are bonded, form a 4- to 10-membered heterocycle,
- wherein n is an integer of 0 to 10;
- Y is —O—, —C(═O)—, —C(═O)—O—, —S—, or —S(═O)2—;
- R8 is a linear or branched C1-10 alkyl, wherein R8 is unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, amino, hydroxyl and C1-6 alkoxy;
- and
- said heterocycle optionally further contain one or two heteroatoms selected from the group consisting of N, O, and S, in addition to the N atom to which R6 and R7 are bonded, and is unsubstituted or substituted with one or more substituents selected from halogen and C1-6 alkyl.
9 more elements
Dependencies are inferred from the claim text.