Fused tetracyclic compounds and uses thereof in medicine

A compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof,

• wherein R1 is R1aO— or RaRbN—;
• X is CR7 or N;
• ring A is a heterocyclyl consisting of 5 ring atoms, a heterocyclyl consisting of 6 ring atoms or a carbocyclyl consisting of 5 to 6 carbon atoms;
• R3 is hydrogen, deuterium, F, Cl, Br, hydroxy, cyano, C1-6 alkyl, C2-6 alkynyl, C3-7 cycloalkyl, heterocyclyl consisting of 3 to 10 ring atoms, C6-10 aryl, heteroaryl of 5 to 10 ring atoms or R10—C0-4 alkylene-O—, wherein each of C1-6 alkyl, C2-6 alkynyl, C3-7 cycloalkyl, heterocyclyl consisting of 3 to 10 ring atoms, C6-10 aryl, heteroaryl of 5 to 10 ring atoms and —C0-4 alkylene- of R10—C0-4 alkylene-O— is independently unsubstituted or substituted by 1, 2, 3 or 4 Rg;
• R10 is deuterium, R11O—, C1-6 alkyl, C3-7 cycloalkyl, heterocyclyl consisting of 3 to 6 ring atoms, C6-10 aryl or heteroaryl consisting of 5 to 10 ring atoms, wherein each of C1-6 alkyl, C3-7 cycloalkyl, heterocyclyl consisting of 3 to 6 ring atoms, C6-10 aryl and heteroaryl consisting of 5 to 10 ring atoms is independently unsubstituted or substituted by 1, 2, 3, or 4 Rj;
• each Rj and Rg is independently deuterium, F, Cl, Br, CN, ═O, HO—, HOOC—, R11O—, R12—S(═O)2—, R13-(C═O)—, R1413 S(═O)2—O—, R1513 S(═O)2—N(Rc)-, R16—N(Rc)—S(═O)2—, R17-(C═O)—N(Rc)—S(═O)2—, amino, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, heterocyclyl consisting of 3 to 10 ring atoms, C6-10 aryl or heteroaryl consisting of 5 to 10 ring atoms, wherein each of amino, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, heterocyclyl consisting of 3 to 10 ring atoms, C6-10 aryl and heteroaryl consisting of 5 to 10 ring atoms is independently unsubstituted or substituted by 1, 2, 3 or 4 Rw;
• each R11, R12, R12a, R13, R13a, R14, R15, R16 and R17 is independently hydrogen, deuterium, RaRbN—, C1-6 alkyl, C2-6 alkynyl, C3-6 cycloalkyl, heterocyclyl consisting of 3 to 6 ring atoms, C6-10 aryl, C6-10 aryl C1-3 alkylene or heteroaryl consisting of 5 to 10 ring atoms, wherein each of C1-6 alkyl, C2-6 alkynyl, C3-6 cycloalkyl, heterocyclyl consisting of 3 to 6 ring atoms, C6-10 aryl, C6-10 aryl C1-3 alkylene and heteroaryl consisting of 5 to 10 ring atoms is independently unsubstituted or substituted by 1, 2, 3 or 4 substituents selected from F, Cl, Br, CN, HO—, ═O, HOOC—, RaRbN—S(═O)2—, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkoxy, C1-6 alkylamino, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-7 cycloalkyl, heteroaryl consisting of 5 to 6 ring atoms, heterocyclyl of 3 to 6 ring atoms, C1-6 alkoxy C1-4 alkylene or C1-4 alkylamino C1-4 alkylene;
• each Rw is independently deuterium, F, Cl, Br, HO—, HOOC—, ═O, amino, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, C2-6 alkenyl, C2-6 alkynyl, tert-butoxycarbonyl, C1-6 alkyl-S(═O)2—, C3-6 cycloalkyl-S(═O)2— or C3-7 cycloalkyl, wherein each of amino, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, C2-6 alkenyl, C2-6 alkynyl, tert-butoxycarbonyl, C1-6 alkyl-S(═O)2—, C3-6 cycloalkyl-S(═O)2— and C3-7 cycloalkyl is independently unsubstituted or substituted by 1, 2, 3 or 4 substituents selected from F, Cl, Br, CN, OH, ═O, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkoxy or C1-6 alkylamino;
• each of R4, R5, R6, R7, R8 and R9 is independently hydrogen, deuterium, F, Cl, Br, R12a13 S(═O)2—, R13a-(C═O)—, C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C2-6 alkynyl, C2-6 alkenyl, C3-7 cycloalkyl, phenyl, heteroaryl consisting of 5 to 6 ring atoms or heterocyclyl consisting of 3 to 10 ring atoms, wherein each of C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C2-6 alkynyl, C2-6 alkenyl, C3-7 cycloalkyl, phenyl, heteroaryl consisting of 5 to 6 ring atoms and heterocyclyl consisting of 3 to 10 ring atoms is independently unsubstituted or substituted by 1, 2, 3, or 4 Rw;
• or R6 and R4, together with the atom to which they are attached, form a carbocyclyl consisting of 5 to 6 ring atoms or a heterocyclyl consisting of 5 to 6 ring atoms, wherein each of carbocyclyl consisting of 5 to 6 ring atoms and heterocyclyl consisting of 5 to 6 ring atoms is independently unsubstituted or substituted by 1, 2, 3, or 4 Rw;
• each R2 is independently hydrogen, deuterium, F, Cl, Br, ═O, C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C2-6 alkynyl, C2-6 alkenyl, C3-7 cycloalkyl, phenyl or heterocyclyl consisting of 3 to 6 ring atoms, wherein each of C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C2-6 alkynyl, C2-6 alkenyl, C3-7 cycloalkyl, phenyl and heterocyclyl consisting of 3 to 6 ring atoms is independently unsubstituted or substituted by 1, 2, 3, or 4 Rw;
• or two R2 linked to the same carbon atom, together with the carbon atom to which they are attached, form a C3-6 cycloalkyl or —(C═O)—, wherein C3-6 cycloalkyl is unsubstituted or substituted by 1, 2, 3, or 4 Rw;
• each R1a, Ra, Rb and Rc is independently hydrogen, deuterium, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C6-10 aryl, heterocyclyl consisting of 3 to 6 ring atoms or heteroaryl consisting of 5 to 10 ring atoms, wherein each of C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C6-10 aryl, heterocyclyl consisting of 3 to 6 ring atoms and heteroaryl consisting of 5 to 10 ring atoms is independently unsubstituted or substituted by 1, 2, 3, or 4 substituents selected from F, Cl, Br, CN, HO—, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 alkylamino;
• n is 0, 1, 2, 3, 4, or 5.