Back to results
US 11,447,495 B2Granted
Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators
AssigneesUWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
InventorsAlexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
Life of this patent
Estimating the term…
Abstract
Substituted benzo[f]imidazo[1,5-α][1,4]diazepines of formula (I′) target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
Claims18
A compound of formula (I):
- or a pharmaceutically acceptable salt or stereoisomer thereof,
- wherein:
- R1 is COOH;
- R2 is C1-4 alkyl, CF3, or CCl3;
- R2′ is H, C1-4 alkyl, or CCl3;
- R3 is Cl, Br, or cyclopropyl;
- and
- X is CF, CCl, CBr, CI, or N.
5 more elements
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.