Back to results
US 11,447,489 B2Granted
Dihydropyrimidinylthiazole for the treatment and prophylaxis of hepatitis B virus infection
AssigneeHoffmann-La Roche Inc.
InventorsXingchun Han, Min Jiang, Yongguang Wang, Song Yang
Life of this patent
Estimating the term…
Abstract
The present invention provides novel compounds having the general formula: wherein R1, R2, X, Y and A are as described herein, compositions including the compounds and methods of using the compounds.
Claims16
A compound of formula (I),
- wherein:
- R1 is phenyl, which is unsubstituted or substituted one, two or three times by halogen or C1-6alkyl;
- R2 is C1-6alkyl;
- X is —(Cy)0-1-(L1)0-1-(L2)0-1-;
- wherein:
- Cy is 3-20 membered heterocyclyl;
- L1 is C1-6alkyl or carboxyC1-6alkyl;
- and
- L2 is O, S, —N(R3)— or —C(O)—NH—, wherein R3 is H or C1-6alkyl;
- Y is a bond, C1-9alkyl, C1-6alkoxyC1-6alkoxyC1-6alkyl or carboxyC1-9alkyl;
- and
- A is formula (A1)
- wherein:
- R4 is hydrogen or C1-6alkyl;
- and
- R5 is hydrogen or C1-6alkoxy;
- or A is formula (A2)
- wherein:
- R6 is hydrogen or halogen;
- R7 is hydrogen or halogen;
- R8 is hydrogen or C1-6alkyl;
- U is a bond or O;
- and
- W is CH or N;
- or a pharmaceutically acceptable salt thereof.
22 more elements
Dependencies are inferred from the claim text.