Class of bifunctional compounds with quanternary ammonium salt structure

A compound represented by formula I, or a pharmaceutically acceptable salt, solvate, optical isomer thereof:

• in formula I, carbons marked with * being all (R) configuration, wherein:
• L is (4-10C) aryl or heteroaryl wherein the hetero atom of the heteroaryl is selected from N, O, and S, the (4-10C) aryl or heteroaryl is unsubstituted or substituted with one or more substituents selected from halogen, —OR1, —SR1, —NR1R2, —NHCOR1, —CONR1R2, —CN, —NO2, —COOR1, —CF3, and C1-C4 linear or branched hydrocarbyl, each of Rand R2 independently is hydrogen atom, C1-C4 linear or branched hydrocarbyl;
• W is independently selected from substituted or unsubstituted (3-6C)cycloalkyl, the substituent is selected from halogen, (1-4C)alkyl, (1-4C)alkoxy, alkoxyhydrocarbyl, and heterocycle;
• R1 is a divalent group —(R1a)d-(A1)e-(R1b)f—;
• wherein d, e, and f are each independently selected from 0, 1, 2 or 3, and the number of adjoining atoms in the shortest chain between two nitrogen atoms to which R1 is attached is in the range of 3 to 14;
• R1a and R1b are each independently selected from (1-10C)alkylene, (2-10C)alkenylene, (1-4C)alkyleneoxy, alkyleneoxyalkyl, alkyleneamido, alkyleneacyloxy, and alkyleneamino, wherein each of alkylene, alkenylene, alkyleneoxy, alkyleneoxyalkyl, alkyleneamino, alkyleneacyloxy, alkyleneamido is unsubstituted or substituted with substituents independently selected from (1-4C)alkyl, chloro, fluoro, hydroxy, phenyl and substituted phenyl, R1a and R1b may be the same or different;
• A1 is independently selected from (3-7C)cycloalkylene, (2-7C)alkylene, (6-10C)arylene, (4-9C)heteroarylene, and (3-8C)heterocycloalkylene, wherein cycloalkylene may be unsubstituted or substituted with 1-4 substituents independently selected from (1-6C)alkyl;
• each of arylene, heteroarylene, and heterocycloalkylene may be unsubstituted or substituted with 1-3 substituents independently selected from halogen, (1-6C)alkyl, (1-6C)alkoxy, —S-(1-4C)alkyl, —S(O)-(1-4C)alkyl, —S(O)2-(1-4C)alkyl, —C(O)—O-(1-4C)alkyl, —NH-(1-4C)alkyl, —N=[(1-4C)alkyl]2, carboxy, nitro, cyano, amido, ester group, trifluoromethyl, and trifluoromethoxy;
• R2 is independently selected from —N(R2a)C(R2b)(O), —C(R2c)(R2d)OR2e, —N(R2f)—, —O—;
• R3 is independently selected from —H, —C(R3a)═C(R3b)—C(O)—, —OC(R3c)(R3d)C(O)—, —N(R3e)CH(R3f)C(O)—, —C(R3g)(R3h)S(O)2—, —SCO—;
• with the provision that R2 is independently selected from —N(R2a)C(R2b)(O), —C(R2c)(R2d)OR2e when R3 is —H;
• with the provision that R2 is —N(R2f)— or —O— when R3 is independently selected from —C(R3a)═C(R3b)—C(O)—, —OC(R3c)(R3d)C(O)—, —N(R3e)CH(R3f)C(O)—, —C(R3g)(R3h)S(O)2—, —SCO—, and R2, R3 and their connected carbon atoms join together to form a ring;
• R2a-2f and R3a-3h are each independently selected from hydrogen and (1-4C)alkyl;
• Y− is selected from Br−, Cl−, I−, bicarbonate, carbonate, bisulfate, sulfate, nitrate, phosphate, hydrogen phosphate, dihydrogen phosphate, phosphite, formate, acetate, propionate, isobutyrate, methanesulfonate, p-toluenesulfonate, benzoate, oxalate, tartrate, fumarate, malonate, succinate, suberate, mandelate, phthalate, benzene sulfonate, citrate, glucuronate, galactonate and amino acid radical;
• and
• T represents a position of hydroxy on the benzene ring, and is selected from the ortho or meta position of R2 on the benzene ring.