Cyclic compound having dopamine D3 receptor antagonistic effect
AssigneeShionogi & Co., Ltd.
InventorsYusuke Ichihashi, Masanao Inagaki, Koji Masuda
Life of this patent
Estimating the term…
Abstract
Novel compounds having a D3 receptor antagonistic activity are provided. The compound represented by Formula (I): wherein Ring A is a non-aromatic heterocycle or the like substituted with substituted or unsubstituted aromatic heterocyclyl or the like; R2a to R2d are each independently a hydrogen atom or the like; n is an integer of 0 to 3; Ring B is a non-aromatic carbocycle or the like; R3 is each independently halogen or the like; r is an integer of 0 to 4; -L- is —N(R10)—C(═O), or the like; R10 is a hydrogen atom or the like; R4 is substituted or unsubstituted aromatic heterocyclyl or the like, or a pharmaceutically acceptable salt thereof.
Claims15
A compound represented by Formula (I):
- wherein a group represented by:
- is
- wherein the dashed line represents the presence or absence of a bond;
- R1a and R1b are each independently substituted or unsubstituted 5- to 6-membered aromatic heterocyclyl;
- R1c is substituted or unsubstituted 5-membered aromatic heterocyclyl;
- R9 is each independently halogen, hydroxy, cyano, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
- two R9 s attached to different ring-constituting atoms may be taken together to form a substituted or unsubstituted (C1-C3) bridge wherein one of carbon atoms constituting the (C1-C3) bridge may be replaced with an oxygen atom or a nitrogen atom;
- s is an integer of 0 to 4;
- R2a is each independently a hydrogen atom, halogen, hydroxy, cyano, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
- R2b is each independently a hydrogen atom, halogen, hydroxy, cyano, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
- R2c and R2d are each independently a hydrogen atom, halogen, hydroxy, cyano, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
- -L- is —N(R10)—C(═O)— or —N(R10)—SO2—;
- a bonding hand “a” is bonded to —CR2cR2d—;
- a bonding hand “b” is bonded to —N(R10)—;
- R10 is a hydrogen atom, or substituted or unsubstituted alkyl;
- Ring B is a 6-membered non-aromatic carbocycle or a 6-membered non-aromatic heterocycle;
- r is an integer of 0 to 4;
- R3 is each independently halogen, hydroxy, cyano, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
- two R3 s attached to different ring-constituting atoms may be taken together to form a bond or a substituted or unsubstituted (C1-C3) bridge wherein one of carbon atoms constituting the (C1-C3) bridge may be replaced with an oxygen atom or a nitrogen atom;
- R4 is substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic heterocyclyl, —CR5aR5b—R6, or —CR7a ═CR7b—R8;
- R5a, R5b, R7a and R7b are each independently a hydrogen atom, halogen, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C1-C6 alkyloxy,
- R6 is substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, or substituted or unsubstituted non-aromatic heterocyclyloxy;
- and
- R8 is substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, or substituted or unsubstituted aromatic heterocyclyl,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.