Compounds active towards nuclear receptors

A compound according to Formula (I)

• a stereoisomer thereof, or a pharmaceutically acceptable salt of the compound or stereoisomer, wherein:
• Y1, Y2 and Y3 are independently —N— or —CR8—;
• m is independently selected from 0, 1, and 2;
• R is selected from the group consisting of hydrogen, C1-6 alkyl and C1-4 hydroxyalkyl;
• R0a and R0b independently are selected from the group consisting of hydrogen, C1-4 alkyl, C1-4hydroxyalkyl, and C1-4 haloalkyl;
• R1a and R1b are independently selected from the group consisting of hydrogen, hydroxyl, halogen, amino, C1-4 alkyl, C1-4 hydroxyalkyl, and C1-4 haloalkyl;
• R2 is selected from the group consisting of hydrogen, hydroxyl, amino, cyano, halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, —C(═O)NH2, —C(═O)OH, —C(═O)O—C1-4 alkyl, and substituted or unsubstituted heteroaryl;
• Ring C is a 3 to 10 membered heteroalicyclyl ring system containing 0, 1, or 2 heteroatoms independently selected from N, O and S in addition to the one N atom shown in the C ring in the compound of Formula I;
• Each R3 is independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl;
• and C1-4 hydroxyhaloalkyl;
• R5 is absent, hydrogen or C1-4 alkyl;
• R6 is selected from the group consisting of hydrogen, —CN, halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 hydroxyhaloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, and substituted or unsubstituted heteroaryl;
• R7 is selected from the group consisting of hydrogen, hydroxyl, —CN, halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, and C1-4 haloalkoxy;
• each R8 is independently selected from the group consisting of hydrogen, hydroxyl, —CN, halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, and C1-4 haloalkoxy;
• and
• whenever R7 is hydrogen and each R8 present is hydrogen, then R6 is selected from the group consisting of —CN, halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 hydroxyhaloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, and substituted or unsubstituted heteroaryl, and
• wherein when substituted, a heteroaryl is substituted with 1 to 3 groups independently selected from the group consisting of C1-4 alkyl, C1-4 hydroxyalkyl, C2-4 alkenyl, C2-4 alkynyl, hydroxy, C1-4 alkoxy, cyano, halogen, C1-4 haloalkyl, C1-4 haloalkoxy and C1-6 hydroxyhaloalkyl.