Back to results
US 11,447,474 B2Granted
Solid forms of a GlyT1 inhibitor
AssigneeBoehringer Ingelheim International GmbH
InventorsJoe Ju Gao, Peter Sieger, Bing-Shiou Yang
Life of this patent
Estimating the term…
Abstract
Disclosed are solid forms of an inhibitor of glycine transporter-1 (GlyT1). The invention also relates to methods of making these solid forms, pharmaceutical compositions comprising these solid forms, and their use for medical conditions responsive to treatment with an inhibitor of glycine transporter-1.
Claims4
A solid Form II of Compound 1 having the structural formula:
- wherein the Form II has characteristic X-ray reflections at the following d values:
- 4.1°, 4.6°, 10.0°, 16.7°, and 18.0° (2-theta);
- or
- characteristic 13C solid-state NMR chemical shifts selected from:
- 130.1 ppm, 46.6 ppm, and 25.0 ppm;
- or
- at least three characteristic 19F solid-state nuclear magnetic resonance peaks at chemical shifts selected from −64.0, −65.6, −66.6, −78.2, and −79.1 ppm.
4 more elements
Dependencies are inferred from the claim text.