Polymorophs of 5-aza-4′-thio-2′-deoxycytidine
AssigneesPinotbio, Inc., Southern Research Institute
InventorsMark J. Suto, Doo Young Jung, Jin Soo Lee, Hyunyong Cho
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Abstract
The present disclosure provides crystalline polymorphs of 5-aza-4′-thio-2′-deoxycytidine. The crystalline polymorphs may be formulated in a pharmaceutical composition, optionally in combination with an additional chemotherapeutic agent. The crystalline polymorphs are useful to treat various diseases including blood cancers, such as myelodysplastic syndrome and leukemia. A process for preparing the crystalline polymorphs of 5-aza-4′-thio-2′-deoxycytidine is also disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims22
A crystalline polymorph of 5-aza-4′-thio-2′-deoxycytidine, wherein the crystalline polymorph has a powder X-ray diffraction pattern that contains peaks at about 8°, about 13°, about 15°, about 17°, about 19°, about 22°, about 23° about 26°, about 28°, about 29°, about 31°, about 33°, and about 37° 2θ.
A crystalline polymorph of 5-aza-4′-thio-2′-deoxycytidine, wherein the crystalline polymorph has a powder X-ray diffraction pattern that contains peaks at about 6°, about 12°, about 13°, about 14°, about 16°, about 18°, about 20°, about 21°, about 22°, about 26°, about 27°, about 29°, about 30°, about 33°, about 35°, about 36°, about 39°, and about 41° 2θ.
Dependencies are inferred from the claim text.