US 11,447,469 B2 · Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof

Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof

AssigneesKorea Research Institute of Chemical Technology, Industry-Academic Cooperation Foundation, Yonsei University

InventorsSung Youn Chang, Hyuk Lee, Ki Young Kim, Bum Tae Kim, Sung Soo Kim, Seong Hwan Kim, Hwan Jung Lim, Jung Nyoung Heo, Sang Joon Shin, Sang Youn Park

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Abstract

The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

Claims8

Dependent claims

A compound of Chemical Formula 1:

or a pharmaceutically acceptable salt thereof,
in the Chemical Formula 1
W is substituted phenyl, pyridyl, thiophene, thiazole, pyrrole, benzothiophene, or indole,
R1 is H or F,
R2 is 1H-indole, 1H-indazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, 3,4-dihydroquinolin-2(1H)-one, indolin-2-one, benzo[b][1,4]oxazin-3(4H)-one, benzo[d]oxazol-2(3H)-one, 2-methyl-1 H-benzo[d]imidazole, 4-methylquinolin-2(1 H)-one, 1,3-dihydro-2H-benzo[d]imidazole-2-thione, benzo[d]thiazol-2(3H)-one, 4-methyl-1H-indazol, 6-methyl-1H-indazol, 4-methyl-1H-benzo[d]imidazole, or 6-methyl-1H-benzo[d]imidazole, or 1H-benzo[d]im idazole.

2 more elements

Dependencies are inferred from the claim text.