IL-17 ligands and uses thereof

A compound of structural Formula (I):

• or a pharmaceutically acceptable salt, solvate or hydrate thereof wherein:
• R1 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl —OR8 or —NR9R10;
• R2 is alkyl, substituted alkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, fused cycloalkylaryl, substituted fused cycloalkylaryl, heteroaryl, or substituted heteroaryl;
• each R3 is independently hydrogen, (C1-C7) alkyl, (C1-C7) substituted alkyl or —OR32;
• m is 0, 1 or 2;
• each R4 is independently hydrogen, (C1-C7) alkyl, or (C1-C7) substituted alkyl, k is 1;
• each R5 is hydrogen or —NR14C(O)R15;
• R6 is hydrogen or alkyl;
• R7 is cycloheteroalkyl, substituted cycloheteroalkyl, —(CHR16)oR17 or —(CHR18)pR19 or R6 and R7 taken together with the nitrogen atom to which they are attached form piperazine, substituted piperazine, cycloheteroalkyl or substituted cycloheteroalkyl,
• R8 is (C1-C7) alkyl, (C1-C7) substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl;
• each R11 is hydrogen;
• n is 1, 2, or 3;
• is 1, 2 or 3;
• p is 1, 2 or 3;
• each R16 is independently hydrogen, (C1-C7) alkyl or (C1-C7) substituted alkyl;
• R17 is
• each R18 is independently hydrogen, (C1-C7) alkyl or (C1-C7) substituted alkyl;
• R19 is —NR27R28;
• R27 and R28 together with the nitrogen atom to which they are attached form a cycloheteroalkyl or substituted cycloheteroalkyl ring or
• and R9, R10, R14, R15, and R32 are independently hydrogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl;
• or R9 and R10 together with atom to which they are attached form a cycloalkyl, substituted cycloalkyl, cycloheteroalkyl or substituted cycloheteroalkyl ring.