Compounds for the degradation of STK4 and treatment of hematologic malignancies

A compound of Formula I:

• or a stereoisomer or pharmaceutically acceptable salt thereof,
• wherein:
• A is phenylene, (C1-C4) alkylene, (C3-C6) cycloalkylene, or heterocyclylene comprising one 5- or 6-membered ring and 1 to 3 heteroatoms selected from N, O, and S, wherein the phenylene, alkylene, cycloalkylene, or heterocyclylene is optionally substituted with one or more (C1-C3) alkyl, (C1-C3) alkoxy, NO2, NH2, or halogen;
• X is NRxS(O)m, S(O)mNRx, NRxC(O), C(O)NRx, or NRx;
• Rx is H, (C1-C3) alkyl, or (C3-C6) cycloalkyl;
• R1 is H, (C1-C3) alkyl, (C1-C3) alkoxy, NO2, or halogen;
• R2 is H, (C1-C3) alkyl, (C1-C3) alkoxy, NO2, or halogen;
• R3 is H, (C1-C3) alkyl, (C1-C3) alkoxy, NO2, or halogen;
• R4 is H, (C1-C3) alkyl, (C1-C3) alkoxy, NO2, or halogen;
• each R5 is independently (C1-C4) alkyl, C(O)NR7R8, CN, OH, or halogen;
• R6 is H, (C1-C4) alkyl, (C1-C4) alkoxy, or halogen;
• R7 and R8 are each independently H or (C1-C4) alkyl;
• m is 0, 1, or 2;
• and
• n is 0, 1, 2, or 3,
• the Targeting Ligand is capable of binding to STK4;
• the Linker is a group that covalently binds to the Targeting Ligand and the Degron;
• and
• the Degron is of Formula D1:
• or a stereoisomer thereof, wherein:
• Y1 is a bond, (CH2)1-6, (CH2)0-6-O, (CH2)0-6-C(O)NR11, (CH2)0-6-NR11C(O), (CH2)0-6-NH, or (CH2)0-6-NR12;
• Z is C(O) or C(R13)2;
• R11 is H or C1-C6 alkyl;
• R12 is C1-C6 alkyl or C(O)-C1-C6 alkyl;
• each R13 is independently H or C1-C3 alkyl;
• each R14 is independently C1-C3 alkyl;
• R15 is H, deuterium, C1-C3 alkyl, F, or Cl;
• each R16 is independently halogen, OH, C1-C6 alkyl, or C1-C6 alkoxy;
• q is 0, 1, or 2;
• and
• v is 0, 1, 2, or 3,
• wherein the Degron is covalently bonded to a Linker via
• wherein:
• when Y1 is (CH2)1-6-O, Y1 can be bonded to the Degron via either the carbon atom or the oxygen atom,
• when Y1 is (CH2)1-6-C(O)NR11, (CH2)1-6-NH, or (CH2)1-6-NR12, Y1 can be bonded to the Degron via either the carbon atom or the nitrogen atom, and
• when Y1 is (CH2)1-6-NR11(O), Y1 can be bonded to the Degron via either the carbon atom in the CH2 moiety or the carbon atom in the C(O) moiety.