Process for the preparation of solriamfetol and salt thereof
AssigneeGlenmark Life Sciences Limited
InventorsShekhar Bhaskar Bhirud, Samir Naik, Jr., Sushanta K. Mishra, Rahul Bhalchadrarao Kawthekar, Deepak Shantaram Patekar, Nitesh Patil
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Abstract
The present invention relates to solriamfetol or novel salts thereof and its process for preparation. More particularly the present invention relates to solriamfetol dibenzoyl-D-tartaric acid salt or solriamfetol di-p-toluoyl-D-tartaric acid salt and their process for preparation. Further the present invention relates to use of solriamfetol dibenzoyl-D-tartaric acid salt or solriamfetol di-p-toluoyl-D-tartaric acid salt for the preparation of solriamfetol hydrochloride.
Claims10
A process for the preparation of R-solriamfetol HCl of Formula Ia,
- the process comprising:
- (a) reacting solriamfetol of Formula I,
- with an acid to form solriamfetol acid addition salt of Formula II;
- (b) optionally purifying the solriamfetol acid addition salt of Formula II;
- (c) converting the solriamfetol acid addition salt of Formula II to solriamfetol HCl of Formula Ia;
- and
- (d) optionally purifying the solriamfetol HCl of Formula Ia.
Solriamfetol dibenzoyl-D-tartaric acid salt of Formula IIa,
- characterized by an 1H NMR having peaks at 2.65-2.71, 2.88, 3.39, 3.72-3.86, 5.69, 6.61, 7.16-7.25, 7.44-7.48, and 7.60-8.00, measured at 400 MHz in DMSO d6.
A process for preparing solriamfetol dibenzoyl-D-tartaric acid salt of Formula IIa,
- comprising reacting solriamfetol of Formula I,
- with dibenzoyl-D-tartaric acid.
Dependencies are inferred from the claim text.