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US 11,447,445 B2Granted
Diabetes and metabolic syndrome treatment with a novel dual modulator of soluble epoxide hydrolase and peroxisome proliferator-activated receptors
AssigneesThe Medical College of Wisconsin, Inc., Johann Wolfgang Goethe-Universität Frankfurt
InventorsJohn David Imig, Md. Abdul Hye Khan, Eugen Proschak, Rene Blocher
Life of this patent
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Abstract
N-benzylbenzamides that act as dual soluble epoxide hydrolase (sEH)/peroxisome proliferator-activated receptor γ (PPARγ) modulators and are useful as medications in the treatment of Metabolic Syndrome (MetS) cluster diseases, including diabetes. Methods of making and using the same are further provided.
Claims22
A compound having the structure:
- wherein:
- X—Y is CH═C or CH2-CH;
- R1 is CH2CH3, CH3 or H;
- and R3 is a fluoro-substituted aryl group;
- or a salt thereof.
2 more elements
Dependencies are inferred from the claim text.