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US 11,446,882 B2Granted
Shaped bone fiber-based products and a method of manufacture thereof
AssigneeBacterin International, Inc.
InventorsTodd Meyer, Helena M. Lovick, Michael Mansfield, Daniel Cox, Gregory Juda
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Abstract
The present invention relates to shaped, bone fiber-based products and methods to make the same.
Claims18
A shaped, dehydrated bone fiber-based product, comprising:
- a plurality of at least partially demineralized bone fibers comprising at least one native growth factor selected from the group consisting of:
- IGF-1 in an amount greater than 60 pg per gram of demineralized bone matrix,
- BMP-2 in an amount greater than 2700 pg per gram of demineralized bone matrix,
- BMP-4 in an amount greater than 200 pg per gram of demineralized bone matrix,
- BMP-7 in an amount greater than 9000 pg per gram of demineralized bone matrix,
- and combinations thereof,
- and having an average length between about 1 and about 200 mm and a void to fiber ratio of between about 1:99 to about 1:11,
- wherein the dehydrated bone fiber-based product, upon rehydration, is within about 60% to about 100% of at least one of a pre-dehydrated shape, a pre-dehydrated flexibility, and a pre-dehydrated compressibility.
5 more elements
A three-dimensionally shaped, fiber-based product, comprising:
- a plurality of at least partially demineralized bone fibers having an average length of about 1 mm to about 200 mm and comprising at least one native growth factor selected from the group consisting of:
- IGF-1 in an amount greater than 60 pg per gram of demineralized bone matrix,
- BMP-2 in an amount greater than 2700 pg per gram of demineralized bone matrix,
- BMP-4 in an amount greater than 200 pg per gram of demineralized,
- BMP-7 in an amount greater than 9000 pg per gram of demineralized bone matrix,
- and combinations thereof;
- and
- a plurality of fibers of a second material selected from the group consisting of wood, food stuffs, plant-based materials, elastomers, thermoplastics, and combinations thereof,
- wherein the fiber-based product comprises a void to fiber ratio of between about 1:99 to about 1:11.
6 more elements
Dependencies are inferred from the claim text.