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US 11,446,654 B2Granted
Substrate with channels for controlled fluid flow
AssigneeQuidel Corporation
InventorsSamantha Chang, Jason McClure, Robert Reed, Irene Sinn Blandy, Robert Weiller, Christian Bobritchi
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Abstract
A substrate structured to define thereon a fluid flow channel and/or a fluid control feature is described. The substrate may additionally comprise a capture zone and/or a test zone, for use as a test strip for determining presence or absence of an analyte of interest, such as an infectious agent or a biomarker. Reagents are deposited in the capture zone and/or test zone as an array of drops.
Claims11
An immunoassay device, comprising:
- a substrate comprised of a plurality of parallel fluid flow channels, wherein each parallel fluid flow channel is separated from an adjacent parallel fluid flow channel by a substrate-devoid gap, and wherein the substrate-devoid gaps form side channels that are impermeable to fluid flow;
- a fluid control feature positioned in each fluid flow channel to form a plurality of fluid flow control features ablated or etched on the substrate;
- a single sample receiving zone positioned on the substrate to distribute a portion of a sample deposited thereon to each fluid flow channel in the plurality of parallel fluid flow channels;
- a label zone in each of the fluid flow channels;
- and
- a capture zone downstream of the label zone in each of the fluid flow channels,
- wherein the label zone, the capture zone, or both the label zone and the capture zone comprise a reagent comprising a binding member.
4 more elements
Dependencies are inferred from the claim text.