High flow, low hold up filters

A filter device comprising:

• a filter element surrounding a central axis and comprising a top end, a bottom end, an external filter surface, an internal filter surface, and an internal space between the central axis and internal surface;
• and,
• a flow director impermeable to liquids and comprising a top end and a bottom end and positioned within the internal space;
• wherein the filter element is closer to the central axis at its bottom end than at its top end, and configured to provide more internal space cross-section between the filter and flow director at the top end of the filter than at the bottom end of the filter;
• wherein a reservoir is positioned above the filter top end in fluid contact and hermetically sealed to the filter top end;
• and,
• wherein the flow director is mounted within the inner space and comprises a smaller cross-section at the flow director top end than a cross-section at the flow director bottom end.