High frequency electromagnetic stimulation for modulating cells, including spontaneously active and quiescent cells, and associated systems and methods
AssigneeNevro Corporation
InventorDongchul Lee
Life of this patent
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Abstract
Electromagnetic stimulation for treating diseases, conditions associated with diseases and/or inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency stimulation in the range of from about 1.5 kHz to about 100 kHz may be applied to a patient's target tissue region to treat the disease, associated condition and/or to inhibit pain. Electrical stimulation in accordance with similar parameters can directly affect a cellular membrane, such as a neuron and in particular, a spontaneously active neuron and/or a quiescent neuron.
Claims27
A method for treating a patient, comprising:
- selecting a frequency value for an electrical signal to be delivered to the patient's spinal cord region based at least in part on a target level of neuronal hyperpolarization, the frequency value being in a frequency range of from about 5 kHz to about 100 kHz and having a positive correlation with neuronal hyperpolarization;
- and
- addressing a condition of the patient by delivering the electrical signal with the selected frequency value to the patient's spinal cord region to hyperpolarize at least some neurons in the patient's spinal cord region, wherein hyperpolarizing the at least some neurons inhibits neuronal activity of the at least some neurons.
A method for treating a patient, comprising:
- programming a signal generator to deliver an electrical signal to the patient's spinal cord region to hyperpolarize at least some neurons in the patient's spinal cord region, the electrical signal having a frequency value selected based at least in part on a target level of neuronal hyperpolarization, the frequency value being in a frequency range of from about 5 kHz to about 100 kHz and having a positive correlation with neuronal hyperpolarization, and wherein hyperpolarizing the at least some neurons inhibits neuronal activity of the at least some neurons.
A method for treating a patient, comprising:
- selecting a frequency value for an electrical signal to be delivered to the patient's spinal cord region based at least in part on a target level of neuronal inhibition of spontaneously active neurons, the frequency value being in a frequency range of from about 5 kHz to about 100 kHz and having a positive correlation with neuronal inhibition;
- and
- addressing a condition of the patient by delivering the electrical signal with the selected frequency value to the patient's spinal cord region to inhibit at least some spontaneously active neurons in the patient's spinal cord region.
A method for treating a patient, comprising:
- programming a signal generator to deliver an electrical signal to the patient's spinal cord region to inhibit at least some spontaneously active neurons in the patient's spinal cord region, the electrical signal having a frequency value selected based at least in part on a target level of neuronal inhibition of spontaneously active neurons in the patient's spinal cord region, the frequency value being in a frequency range of from about 5 kHz to about 100 kHz and having a positive correlation with neuronal inhibition.
Dependencies are inferred from the claim text.