Stimulation of a nerve supplying the spleen

A system for stimulating neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, the system comprising:

• at least one electrode configured to be in signaling contact with the nerve supplying the spleen;
• and
• at least one controller electrically coupled to the at least one electrode, the at least one controller configured to control operation of the at least one electrode to apply an electrical signal having a charge density to the nerve, wherein the charge density per phase applied to the nerve by the electrical signal is ≥70 μC per cm2 per phase and >1100 μC per cm2 per phase, the electrical signal capable of producing an improvement in a physiological parameter in a subject, wherein the improvement in the physiological parameter is one or more of the group consisting of:
• a reduction in pro-inflammatory cytokines, an increase in anti-inflammatory cytokines and/or pro-resolving mediators, an increase in catecholamines, changes in immune cell population or immune cell surface co-stimulatory molecules, a reduction in factors involved in an inflammation cascade, and/or a reduction in immune response mediators.