Treatment of disorders associated with inflammation

A system for stimulating neural activity of a splenic arterial nerve, the system comprising:

• at least one electrode in signaling contact with the splenic arterial nerve at a site where a splenic artery is not in direct contact with a pancreas;
• and
• at least one controller electrically coupled to the at least one electrode, the at least one controller configured to control operation of the at least one electrode to apply an electrical signal to the splenic arterial nerve, wherein a charge density per phase applied to the splenic arterial nerve by the electrical signal is between 70 μC to 1100 μC per cm2 per phase, wherein the electrical signal produces an improvement in a physiological parameter in a subject, and wherein the improvement in the physiological parameter is one or more of a group consisting of:
• a reduction in a pro-inflammatory cytokine, an increase in an anti-inflammatory cytokine, an increase in a catecholamine, a change in an immune cell population, a change in an immune cell surface co-stimulatory molecule, a reduction in a factor involved in an inflammation cascade, a change in a level of an immune response mediator, and a decrease in splenic blood flow.