Attenuation of encrustation of medical devices using coatings of inorganic fullerene-like nanoparticles
AssigneesYeda Research and Development Co. Ltd., Mor Research Applications Ltd.
InventorsReshef Tenne, David Zbaida, Racheli Ron, Ilan Kafka, Ilan Leibovitch
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Abstract
A new approach is presented to reduce encrustation of catheters by the application of nanoparticles. It is demonstrated that the negatively surface charged nanoparticles produce coating films comprised of long-range domains in which the nanoparticles are self-assembled into a mosaic-like order, showing a relatively small tendency to agglomerate.
Claims21
An implantable or insertable medical device in a body of a subject, coated on at least one surface region thereof with a non-adherent film, said film consisting of inorganic nanoparticles, wherein the inorganic nanoparticles are inorganic fullerene-like nanoparticles (IF nanoparticles), or inorganic nanotubes (INT), wherein the inorganic nanoparticles being of the general formula A1-x-Bx-chalcogenide, wherein A is a metal or a transition metal or an alloy of such a metal/transition metal, B is a metal or a transition metal, and x being ≤0.3 and different from zero, provided that:
- A≈B;
- wherein said film comprises domains displaying self-assembly of said nanoparticles into closed-packed arrays with a mosaic appearance, wherein said surface is made of silicones or plastics;
- wherein said inorganic nanoparticles are attached directly to the device surface;
- wherein said film does not comprise a coating matrix or a coating composite substrate in which the nanoparticles are embedded;
- and wherein said at least one surface region of the device is intended for direct contact with at least one inner-body tissue of a subject's body.
An implantable medical device or an insertable medical device in a body of a subject configured to be implanted in a subject, the device comprising an implantable unit or structure, wherein at least a surface region of said unit or structure being coated with a non-adherent film of inorganic nanoparticles, wherein the inorganic nanoparticles are inorganic fullerene-like nanoparticles (IF-nanoparticles) or inorganic nanotubes (INT) adapted to prevent or inhibit deposition of encrustation and/or formation of a biofilm thereon after implantation in the subject;
- wherein said film comprises domains displaying self-assembly of said nanoparticles into closed-packed arrays with a mosaic appearance wherein said surface is made of silicones or plastics;
- wherein the inorganic nanoparticles being of the general formula A1-x-Bx-chalcogenide, wherein A is a metal or a transition metal or an alloy of such a metal/transition metal, B is a metal or a transition metal, and x being ≤0.3 and different from zero, provided that:
- A≈B, wherein said inorganic nanoparticles are attached directly to the device surface;
- and wherein said film does not comprise a coating matrix or a coating composite substrate in which the nanoparticles are embedded.
A process for reducing, diminishing or preventing the formation of encrustations on a surface region of an implantable medical device or insertable medical device in a body of a subject, the process comprising forming a non-adherent coating or a film of inorganic nanoparticles, wherein the inorganic nanoparticles are inorganic fullerene-like nanoparticles (IF-nanoparticles) or inorganic nanotubes (INT) on said surface region prior to implanting or inserting said device into a body tissue, organ or body lumen, wherein said film comprises domains displaying self-assembly of said nanoparticles into closed-packed arrays with a mosaic appearance, wherein said surface is made of silicones or plastics;
- and wherein the inorganic nanoparticles being of the general formula A1-x-Bx-chalcogenide, wherein A is a metal or a transition metal or an alloy of such a metal/transition metal, B is a metal or a transition metal, and x being ≤0.3 and different from zero, provided that:
- A≈B, wherein said inorganic nanoparticles are attached directly to the device surface;
- and wherein said film does not comprise a coating matrix or a coating composite substrate in which the nanoparticles are embedded.
Dependencies are inferred from the claim text.