Composition and methods for antimicrobial articles
OwnerSolomon Rosenblatt, John P. Kennedy +1inventors
InventorsSolomon Rosenblatt, John P. Kennedy, Curtis E. Jones
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Abstract
A biocompatible controlled release form of complexed iodine is achieved by a complexation of polyvinyl alcohol based foam and characterized by a residual starch component to optimize iodine release profiles. The resulting iodine complexed polyvinyl alcohol foam may be utilized locally as an antimicrobial agent that releases controlled amounts of iodine sufficient to kill microbes for extended durations without excessive bulk and rigidity.
Claims28
A method for treating a wound of a patient in need thereof, said method comprising:
- (a) providing a polyvinyl alcohol (PVA) foam article comprising an iodophor, wherein the PVA foam article has a density of at least 0.078 g/cm3, wherein the PVA foam article comprises PVA foam, starch, and iodine;
- wherein the iodine is complexed at least in part to the PVA foam and the starch to form said iodophor;
- and
- (b) applying the PVA foam article to a tissue of the patient for at least 24 hours, wherein the tissue has a wound.
A method for treating a wound of a patient in need thereof, said method comprising:
- (a) providing a polyvinyl alcohol (PVA) foam dressing comprising an iodophor, wherein the PVA foam dressing has a density of at least 0.078 g/cm3, wherein the PVA foam dressing is produced by a method comprising:
- mixing PVA and a starch pore former in a slurry, adding an aldehyde to the slurry to produce a foam, and washing the foam to produce a PVA foam containing residual starch, and complexing iodine at least in part to the PVA foam and the residual starch to form said iodophor;
- and
- (b) applying the PVA foam dressing to a tissue of the patient, wherein the tissue has a wound.
A method for delivering iodine to a patient in need thereof, wherein the method releases iodine for at least 24 hours as an effective antimicrobial agent;
- said method comprising:
- (a) providing a biocompatible polyvinyl alcohol (PVA) foam dressing comprising (i) PVA foam, (ii) residual starch within the PVA foam, and (iii) iodine;
- wherein the iodine is complexed at least in part to the PVA and the residue starch to form an iodophor;
- and
- (b) applying the PVA foam dressing to a tissue of the patient, wherein the tissue has a wound.
A method for treating a wound of a patient in need thereof, said method comprising:
- (a) providing an iodophor comprising PVA foam, a starch, and iodine;
- said PVA foam and starch in solid form, both PVA and starch complexed with iodine;
- and
- (b) applying the iodophor to a tissue of the patient, wherein the tissue has a wound.
Dependencies are inferred from the claim text.