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US 11,446,394 B2Granted
Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery
AssigneeNutcracker Therapeutics, Inc.
InventorColin James McKinlay
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Abstract
The present disclosure relates to lipid mixtures comprising lipidated cationic peptide compounds, such as tertiary amino lipidated and/or PEGylated cationic peptide compounds or lipitoids, for nucleic acid delivery. More specifically, the present disclosure relates to lipid nanoparticle formulations comprising lipidated cationic peptide compounds and other lipid components including structural lipid, phospholipid and shielding lipids. The present disclosure also relates to methods of preparing and using the lipid mixtures.
Claims26
A composition, comprising complexes of:
- one or more polyanionic compounds;
- and
- lipid components, wherein the lipid components comprise:
- (i) optionally one or more structural lipids;
- (ii) one or more phospholipids;
- (iii) one or more shielding lipids;
- and
- (iv) one or more tertiary amino lipidated and/or PEGylated cationic peptide compounds of formula (I) or salts thereof:
- wherein:
- s is an integer from 1 to 5;
- R1 is —H;
- each R3 is independently selected from C8-C24alkyl;
- R5 is selected from aminoalkyl, aminoalkylaminoakyl, and hydroxyalkyl;
- R7 is —NH2;
- and
- each Ra and Rb are independently.
13 more elements
Dependencies are inferred from the claim text.